THE MECHANISM OF COMPLEMENT FIXATION

The Mechanism of Complement Fixation

1. Complement fixation is obtained in every antigen-antibody reaction involving the presence or formation of a heterogeneous phase (red cells, bacteria, precipitate). 2. The physical constants of fixation (temperature coefficient, velocity, quantitative relationships between the reactants) are those commonly associated with adsorption processes, and are the same in the three types of fixation s...

The Gomez Complement-fixation Reaction

Much has been done, but there is still much to be accomplished in the matter of tests for infection and immunity in leprosy. To be of help to the clinicians it is not sufficient for a test to be positive among the inmates of a leper asylum; it is necessary that it should work also in free surroundings where are met the doubtful cases, toward the' detection of which the greatest vigilance should...

Indirect Complement Fixation in Foot-and-Mouth Disease

Studies on Complement Fixation

It is shown by complement fixation studies with protein antigens and specific immune rabbit sera that the rate of fixation of complement is determined by the concentration of antibodies in the immune sera, that the greater part of fixation of complement takes place during the 1st hour, and that fixation is practically completed at the end of 4 hours at ice box temperature. It is further shown t...

The Diagnosis Of Glanders By Complement Fixation